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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A study of oral contraceptive use found a risk of breast cancer in long-term (> 12 years) higher dose oral contraceptive users odds ratio = 2.33 (95% CI = 0.9-3.2). Which of the following statements most accurately assesses the study's conclusion that there is a modest effect of oral contraceptive use on breast cancer risk in young women?

A) The conclusion is justified statistically because the odds ratio is significant.
B) The conclusion is understated because the odds ratio is greater than two times the nonuser risk.
C) The conclusion is not justified statistically because the odds ratio is nonsignificant.
D) The conclusion cannot be evaluated until the odds ratio is converted to relative risk.

2. An obtunded 61-year-old Woman weighing 45 kg with Worsening renal function is admitted to the hospital. She has a recent history of several days of nausea, fatigue, pruritus, and a metallic taste in her mouth. Her medical history includes diabetes, heart failure, and COPD. Admission laboratory values include:
SERUM CHEMISTRY
Sodium: 135 mEq/L
Potassium: 5.7 mEq/L
Chloride: 100 mEq/L
HCO3: 15 mEq/L
BUN: 96 mg/dL
Creatinine: 5.5 mg/dL
Glucose: 300 mg/dL
Calcium: 7.4 mg/dL
Serum ketones: Negative
ABGS (Room Air)
pH: 72
PaCO2: 30 mm Hg
PaO2: 75 mm Hg
O2 Sat: 90%
Chest X-ray shows a flattened diaphragm. Current medications include furosemide, fluticasone salmeterol, and glipizide. Which acid-base disorder does this patient exhibit?

A) Respiratory acidosis secondary to COPD
B) Metabolic acidosis secondary to furosemide use
C) Metabolic acidosis secondary to end-stage renal disease
D) Metabolic acidosis secondary to diabetic ketoacidosis

3. A 46-year-old patient begins treatment with allopurinol 300 mg daily following the onset of an acute gout attack due to elevated uric acid.
The patient's other medications are:
* Cyclosporine 800 mg daily
* Prednisone 20 mg daily
* Azathioprine 100 mg daily
* Nifedipine extended release 90 mg daily
Several days later there was an observed decrease in the patient's WBC count. Which drug interaction with allopurinol is most likely to account for this change?

A) Nifedipine
B) Cyclosporine
C) Azathioprine
D) Prednisone

4. What provides the best economic justification of the addition of a clinical pharmacist to a 200- bed - community hospital?

A) Drug protocol management
B) Discharge medication counseling
C) Participation on a nutrition support team
D) Participation in interprofessional committees

5. After 9 days of hospitalization, a 60-year-old 60-kg patient has a temperature of 39.4°C and a WBC count of 20,000 cells/uL. A sputum sample shows numerous WBCs and Gram-negative bacilli. The serum creatinine is 1.0 mg/dL. For this patient, which of the following drugs would be most appropriate for initial parenteral therapy?

A) Aztreonam, clindamycin, and vancomycin
B) Ceftriaxone and azithromycin
C) Cefepime, levofloxacin, and vancomycin
D) Tobramycin and cefepime

Solutions: